Don't round off the spine. When you go to fit your handles, you will be left with gaps after they are epoxied on, and it cant be fixed short of grinding them down, thus changing your handle shape slightly =(
I'm not sure 100% on the reasons for the sanding directions.. but from what I gathered when doing my first knife, it is MUCH easier to get uniform and straight scratch lines sanding length wise. While you do have to switch up the scratch pattern to find some pesky deeper scratches... finishing up with a lengthwise sand will always yeild a better looking finish I think... (someone please correct me if I'm wrong on that though

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