I generally have one knife in my back pocket, and one in the front (both on the right side). The front pocket holds a little one, like a barlow or a small jack; the back one is where the larger one rides, like a fill-size coke bottle, toothpick, folding hunter, or daddy barlow, tucked in next to a bandana to keep it sitting up vertically.
It's a good carry method for me. In my experience, the front pocket is more likely to let a knife slip out, never from the back (if I'm sitting in a chair, then my butt's on top of it, so it's not going anywhere... and if I'm in a car seat that slopes down at the rear, then the front pocket is the one that turns upside-down-ish allowing a knife to slip out, while the back pocket is again underneath my hiney...). Maybe this is because my jeans are snug enough that the back pocket knife generally stays put. If I wore loose, floppy pants, I could imagine that things might work out differently (but I can't stand to wear over-size clothing... makes me feel like it's 1994 again and Kris Kross is on the radio).
So... if you want to give it a try, your knife should be fine; and, depending on how you wear your pants, it could be a secure and comfortable carry option.