I own both a Buck 110 and a Spyderco Military. I use the 110 primarily for cutting thick, tanned cowhides (3/16ths-1/4 inch thick). I like the 110 for that job over the Military for three reasons- 1. It has a paper-thin edge (great for cutting through thick leather), 2. It has a handle that I find comfortable to use for long periods of time with a firm grip, 3. It has a solid feel in my hand during use.
The Military is a good knife, but it has a thicker edge than the 110, I find the handle to be uncomfortable with extended use and a firm grip (the lock, and the g10 handle next to the lock will immediately start to dig into my finger). And it has a certain amount of "flex" in it that I don't like (thin g10 handles, only one thin titanium liner).
For me, the advantages the Military has over my 110 are- lightweight, one-hand opening, pocket clip, higher grade of steel (mine is an older model, CPM 440V blade). If I were going to be carrying a knife in my pocket all day, and use it infrequently for brief moments, I would choose the Military. But if I were at home and needed to cut a full cowhide into smaller pieces I'd use the 110. Two very different knives, each with their own virtues.