Corona thread. No politics please

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Standard78 said:
On a lighter note, The Air Force has had two flyovers out here in SoCal to show appreciation to our First Responders and Healthcare Workers and I just have to say, it was frickin’ amazing!!
Yesterday we had a C-17 and KC-135 do a ridiculously low flyover, and today the Thunderbirds flew so damn low I actually ducked down for a second!

Hot damn, I love this Country!
What an adrenaline rush!
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I saw the Thunderbirds flying on my local news channel and IIRC, they they also did a missing man formation in the honor of the first responders who had sacrificed themselves? Awesome stuff :thumbsup: :thumbsup:
 
Casinostocks said:
"I do what I damn wanna do, when I choose to do it and wherever it darn pleases me to" Also, "I'm a constitutional expert and scholar because I have tattooed: WE THE PEEPLE on my forearm" :)
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And the sad part is that the mentality/behavior is quite apolitical. Some may try to infer that there's a political motif behind it, but it just boils down to selfish entitlement. All the freedom. None of the responsibilities that come with it.
 
Casinostocks said:
I saw the Thunderbirds flying on my local news channel and IIRC, they they also did a missing man formation in the honor of the first responders who had sacrificed themselves? Awesome stuff :thumbsup: :thumbsup:
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It really makes me miss living on base housing at El Toro and all of the time I spent at March AFB as a youngster.

I may have to take a stroll out to Miramar soon to get my fill.
 
Nathan the Machinist said:
I'm pretty open minded and accepting of folks with a different point of view than mine. I'm fine getting along with someone I disagree with. We have a regular here who literally believes the earth is literally flat (which I don't personally agree with) and while I don't enjoy debating about the shape of the earth I do enjoy him and his presence on the forum. We get along...

Snip
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How do you know for certain that he is regular? I contend that he is in fact irregular and has a flat head instead of a round shaped head like almost everyone else. Unless I see and verify this assumption for myself and in person, I propose that his head is shaped like a plank and hence, very irregular!
 
bluemax_1 said:
All over the industry news.

I would categorize my opinion under, "cautious optimism pending further research".
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My thoughts so far also.

They aren’t praising it by any means, but there is quite a bit of chatter on it.

I just moved so there’s no cable channels to watch until this virus crap is over. I don’t want to risk having a cable guy in my house just yet.
 
Standard78 said:
My thoughts so far also.

They aren’t praising it by any means, but there is quite a bit of chatter on it.

I just moved so there’s no cable channels to watch until this virus crap is over. I don’t want to risk having a cable guy in my house just yet.
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Yup. In vitro testing is one thing. There are other considerations for in vivo testing.

As for cable, my memory/knowledge in the area isn't the best, but maybe there's a contactless option? Unless there's a need to actually run the cable and install the connection, I thought you could just connect the box yourself (i.e. have it shipped/dropped off on your doorstep and decon the box).

The cable guy usually just needs to access the box on the outside. Maybe try calling the cable company and asking if 'no-contact/ entry' is an option if it's something desirable?
 
if regularity is a problem, I suggest adding some fibre to your diet. Try and take one thing that you eat more or less regularly that doesn't have a lot of fibre and try to find a fibrous replacement. Start with small things that you barely notice and keep going until you've achieved better balance. Before long you'll be shitting like a hero
 
bluemax_1 said:
Yup. In vitro testing is one thing. There are other considerations for in vivo testing.

As for cable, my memory/knowledge in the area isn't the best, but maybe there's a contactless option? Unless there's a need to actually run the cable and install the connection, I thought you could just connect the box yourself (i.e. have it shipped/dropped off on your doorstep and decon the box).

The cable guy usually just needs to access the box on the outside. Maybe try calling the cable company and asking if 'no-contact/ entry' is an option if it's something desirable?
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I’ll have to keep my eye out on this antibody. It could be a magical cure, or it may be snake oil to boost stocks.

As far as cable goes, my issue here is that the house has never had cable in 70 years so there is no drop from the pole.
I may need to get under the house and route it to the eave where the old phone line is, then have those yahoo’s do the rest.
 
Standard78 said:
I’ll have to keep my eye out on this antibody. It could be a magical cure, or it may be snake oil to boost stocks.

As far as cable goes, my issue here is that the house has never had cable in 70 years so there is no drop from the pole.
I may need to get under the house and route it to the eave where the old phone line is, then have those yahoo’s do the rest.
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Yep. That's the reason for "cautious optimism". Hope is a good thing, but there've already been other 'pump n dumps' taking advantage of this pandemic.
 
https://www.medrxiv.org/content/10.1101/2020.05.02.20080036v1.full.pdf

Brief summary:
Study on Hydroxychloroquine, Azithromycin and Zinc Sulfate.
- Given early, the therapy is showing effectiveness. Once the viral load has increased too much and other issues have begun, effectiveness is markedly decreased (as is the case with many medications that exhibit antiviral properties, eg. Tamiflu. Taken early, they help. Taken late, when the viral load is too high, they're of minimal benefit).
- Hydroxychloroquine and Azithromycin therapy seems to work better with zinc. Hydroxychloroquine acts as an ionophore, allowing the zinc to enter the cells where it has strong action inhibiting viral replication
- Zinc without Hydroxychloroquine seems to have minimal benefit.


*** Quercetin (available online) appears to have some level of activity as an ionophore for zinc.

https://www.ncbi.nlm.nih.gov/pubmed/25050823
 
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#notanmd #notadoctor

In a rudimentary way, what happens when a person is inoculated say with flu vaccine, a very low dosage of the virus in addition to other chemicals is injected I to the body so that the one's own immunity system mobilizes to counteract and defeat the virus. The exact scientific explanation from virus to virus is far too complex (based on any specific pathogen and what proteins within a host it needs to survive, if any) so for the sake of brevity I stick with thew simple and layman explanation.

Taking our own country as our example without delving into other countries (too many geographic, ethnicity, racial, cultural, customs, healthcare, etc variances to consider) we have already seen that in our most populated state in the union, CA, the transmission, contraction and mortality rates have been far less than NY & NJ. While CA is not the largest state in the union, it is still a massive state with most of its population concentrated in a handful of cosmopolitan cities pretty much like NYC. The huge disparity between the numbers can safely lead us to believe that constant exposure to high volume and dosages of this virus in more populated environments (take nursing homes and prisons for example where the occupant immunity systems are also on the lower end) are far more morbidly harmful as opposed to much lower dosage exposures.

When the scientists and the experts advocate for mitigation methods such as social distancing and donning on face-masks, gloves and goggles if and when possible, these are the recommended measures in order to hopefully building immunity by way of being exposed to very low dosages in absence of an effective vaccine. To me it is preposterous that some people for sake of ideological dogma and some BS tough guy facade, just refuse to acknowledge that taking some minimal precautions such as wearing face-masks when in public is really for the benefit of the said person in addition to the public at large.

As a closing note, the 1918 Spanish flu pandemic caused about 675K American deaths which are about the same numbers as the Civil War. In 1918 our populace was more reticent and complaint with Government given mandates as opposed to some of the yahooery (new word) which we witness today. People were still divided ideologically back then as they are today belonging to our two separate political tribes but it seems to me that even a full century ago, people seemed to have been more cognizant, polite and respecting toward one another with less of this me-me-me attitudes. To the me-me-me types: go fuck yourselves royally.

Signed, Dr. Uncle Matty :)
 
Casinostocks said:
#notanmd #notadoctor

In a rudimentary way, what happens when a person is inoculated say with flu vaccine, a very low dosage of the virus in addition to other chemicals is injected I to the body so that the one's own immunity system mobilizes to counteract and defeat the virus. The exact scientific explanation from virus to virus is far too complex (based on any specific pathogen and what proteins within a host it needs to survive, if any) so for the sake of brevity I stick with thew simple and layman explanation.

Taking our own country as our example without delving into other countries (too many geographic, ethnicity, racial, cultural, customs, healthcare, etc variances to consider) we have already seen that in our most populated state in the union, CA, the transmission, contraction and mortality rates have been far less than NY & NJ. While CA is not the largest state in the union, it is still a massive state with most of its population concentrated in a handful of cosmopolitan cities pretty much like NYC. The huge disparity between the numbers can safely lead us to believe that constant exposure to high volume and dosages of this virus in more populated environments (take nursing homes and prisons for example where the occupant immunity systems are also on the lower end) are far more morbidly harmful as opposed to much lower dosage exposures.

When the scientists and the experts advocate for mitigation methods such as social distancing and donning on face-masks, gloves and goggles if and when possible, these are the recommended measures in order to hopefully building immunity by way of being exposed to very low dosages in absence of an effective vaccine. To me it is preposterous that some people for sake of ideological dogma and some BS tough guy facade, just refuse to acknowledge that taking some minimal precautions such as wearing face-masks when in public is really for the benefit of the said person in addition to the public at large.

As a closing note, the 1918 Spanish flu pandemic caused about 675K American deaths which are about the same numbers as the Civil War. In 1918 our populace was more reticent and complaint with Government given mandates as opposed to some of the yahooery (new word) which we witness today. People were still divided ideologically back then as they are today belonging to our two separate political tribes but it seems to me that even a full century ago, people seemed to have been more cognizant, polite and respecting toward one another with less of this me-me-me attitudes. To the me-me-me types: go fuck yourselves royally.

Signed, Dr. Uncle Matty :)
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Hopefully, this isn't taken the wrong way, the general gist is good, but I thought it might be a good thing to clarify a few points to make things clearer/easier to understand for the folks following/perusing the thread.

*** for folks who might be interested in a little more depth, consider reading up on the differences between the innate vs adaptive and cellular vs humoral immune response.

- many vaccines (including the annual flu shot) use inactivated virus. The whole ,"the flu shot gave me the flu" simply isn't possible, because the virus is inactivated and can't replicate. The actual dose though, isn't low, it's fairly high compared to the viral load it would take to cause an infection in a healthy person.

The adaptive/humoral response recognizes the inactivated virus as an attacker, and triggers the production of antibodies against the virii in the vaccine.

It IS possible to experience mild symptoms from a flu shot, because these are part of an individual's immune response to an infection (eg. A fever isn't directly caused by the pathogen, it's caused by the body's own responses to infection by a pathogen), but the symptoms are milder because there's no active infection, and no increasing viral load.

The exception are vaccines that use LAV (Live Attenuated Virus, eg. The nasal spray version of the flu vaccine). These actually DO use live virus that produce a mild infection (attenuated to mute the virulence), because some people (eg. children with the influenza vaccine) don't produce a strong response (high enough antibody titer) with the inactivated virus vaccines.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4219018/

As for the mitigation measures like social distancing and PPE: it's basically a 'time and intensity' play, both on the individual as well as societal scale.

A little insight/detail: while it's potentially possible for a single active virion to result in an infection, the probability is highly unlikely. An individual with a strong/healthy immune system likewise potentiality clears a small viral load via the innate/cellular response more readily than someone with a weaker immune system.

On the individual scale, the 'time and intensity' factor comes into play because a lower initial viral load can result in a case with lower severity and/or a longer time interval to increase in severity. The time interval is crucial to medical intervention if necessary, as opposed to the patient's immune system being overwhelmed rapidly, followed by cascading effects on the body's vital functions.

Depending on the individual though, too low an initial viral load, may not trigger the adaptive/humoral immune response if the pathogens are cleared rapidly by the innate/cellular response, and therefore without the resultant antibodies, there is no conferred immunity.

It's not like increasing your tolerance for spicy food by gradually increasing the amount you're exposed to. You're either exposed to an amount that triggers the production of antibodies, or not (and obviously, different individuals immune systems will produce higher or lower levels of antibodies).

Decreasing the initial viral load on exposure can play a critical role in the severity of a person's illness upon infection. Decreasing your exposure in total, reduces your chances of being infected in the first place.

On the societal scale, mitigation measures help to reduce the intensity of the local epidemic, which reduces the burden on the healthcare system and hospitals, and increases the amount of time to ensure sufficient PPE/medications/equipment, as well as develop/test effective treatments and/or vaccines.

If we can't develop a viable vaccine, based on an estimated native R0 around 6, we'd need somewhere around 80% of the population to be infected and recovered for effective herd immunity (assuming that recovery = immunity). If the CFR is even 1% instead of the 3-5% we're seeing worldwide right now, that would be ~2.6 million deaths in the US.

Conversely, if everyone simply came together and exhibited personal responsibility and common courtesy in the application of mitigation measures (maintain social distancing, wear PPE when in public, stay home if you're sick), we could effectively squash the spread enough to drop the R0 below 1. Coupled with rapid, effective and available testing and we could reopen many things while quickly managing any new outbreaks or clusters that pop up.
 
^ yup, my acerbic tone may ruffle some feathers but I have ZERO tolerance for those who are in denial whose ways may affect me and mine very directly, despite all the precautions which I personally take.

I have been taking care of our Mom ever since my Dad passed away in 1998 when he was barely in early 60's (an accident as sh*t happens, he lived his life quietly largely and always looked at the breadth not the length, so no sympathy is sought). These days I not only care for Mom financially but in the past 8 years she has actually been living with me, hence my stay at home work habits and spending copious amounts of time online, etc...

My dread and nightmare is catching it and then giving it to her, despite the fact that she is now totally isolated and has not even had her regular physician visits since mid Feb 2020. Even my kids will have to be extra caution when visiting G'Ma. Hence, I have no love for COVID-19 fucktards.

But thank you for trying to clean up my post :thumbsup:
 
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