Have you held either of these? Sorry, but aside from the blade steel, this seems like and apples v. oranges debate. It will come down to which carries better and which feels nicer in the hand.
The Mule, by Ka-bar, will likely hold the better edge. However this is a very big knife for a folder. It fits well for people with large hands. It has no clip. Instead it comes with a nylon belt sheath. It opens slowly compared to most folders. I would consider it a two handed opener/closer, almost.
The M-16 is much lighter and carries very nicely in the pocket. If you haven't got huge mitts, I would recomend this one.
Both knives are manufactured in Taiwan. The Mule will have a stronger lock, but the M-16 holds up just fine for edc use, especially with the LAWKS system. Unless you do a lot of very demanding work with your blade, you would likely be happier with the CRKT. If you would like the best of both worlds, I would recomend the M1 by CRKT. Opens easier than the M-16. Heavier than the M-16 but lighter than the Mule. And it fits better in larger hands.