It's a mix of variables at play.
Custom/handmade price determined by value of time (of maker), investment made (machines/tools), tolerances, detail work, percieved value of brand, value of materials used, cost of production technicques applied (EDM, etc).
With production knives prices are determined by economy of scale, materials used, royalties to be paid, automation, overheads, cost of labour, marketing, value of brand and production techniques.
In all cases supply and demand plays a role. If the demand is healthy at a particular price point then why charge less? Maximum profit is important for any business, and making/manufacturing knives is a business. As long as there is a demand for a Strider at $500 it will be sold for $500.
A Spyderco PM2 is a great knife and can do what a Sebenza can do but Sal is the first person that will tell you a PM2 is not a Sebenza. Sal himself will talk about tolerances that cannot be matched at lower prices. This means the Sebenza is incredibly accurately made which means that every component will be perfect which will result in a superior user experience and reliability. The long series of Blade Show Manufacturing Quality Awards is proof of this in the CRK case. You get what you pay for in the CRK case.
Unfortunately this is not true in all cases. There will always be a number of chancers in the industry that fake it to make it big. Unfortunately a large % of these get away with it because a small % of $500 buyers actually use their knives. The bad boys are therefore seldom identified and dealt with. It is therefore critical that buyers be smart enough to choose well from the outcome of research done. Anyone buying a $500 knife without doing research deserves the pain if it comes. With a $150 knife the risk is low so the pain is a lot less if things were to go wrong.