Depends on where I am, who I'm with, what I'm doing, what I anticipate posing a problem, and how much gear I'm willing to pack.
I'm always packed, and the caliber increases in direct proportion to the size of - and number of legs on - the critter. To remain topical:
My family spends a LOT of time in the mountains, and I hunt Antelope, Deer, Elk, and Bear during their respective seasons. Where I'm hiking/camping (and how I got there), and where/what I'm hunting, all makes a difference in what I take along. Rarely, for example, do I carry a handgun on a hunt unless I'm tagged out and just hauling meat. We've had a recent spate of bear trouble in some of my regular wilderness haunts, last year we had a rutting 6x6 in our summer camp, so the possibility of an issue is always there.
We always have a "heavy" rifle in camp, we always have a couple of handguns available, we always have at least one .22lr for plinking, camp meat and educational purposes.