The pocket for one thing.....don't get me wrong, I don't want to talk you out of it, I am going to buy a RAO myself and have the funds pretty much together. But to argue that it is functionally equal or superior to a more average sized folder I find quite questionable. The "thing" a "pocket knife" most commonly encounters is....the pocket. The RAO is almost exactly TWICE as heavy as a full size Manix. It is about 0.75" wider and over an inch longer. Not surprisingly, it comes with a sheath instead of a clip.
As far as cutting goes, sure you have to look at the whole geometry, but clearly, in any task in which the entire blade is inserted in the material, such as cardboard, the blade displaces a 1/4" wide section, which adds a lot more friction than an 1/8" section for example. Of course this applies only to knives that have a very similar geometry near the edge.
So what do you really need the 1/4" blade for? I buy the RAO half for kicks and giggles and half because it is an uncompromising design. But I would never argue that it makes an equal or better slicer than some other designs (even though it probably makes a decent slicer at this blade height), or that it is as comfortable to carry or as comfortable to use. Few people have hands of sufficient size to find these ultra thick and large folders comfortable, let alone to benefit from them. The other thing is that the RAO is one of the few designs where the hole package fits the blade. I am certain that I will offend some people by saying this, but to sell a Strider with a 1/4" blade but a 1/4" long, 0.050" thick cutout in the Ti frame lock lockbar (as for example shown in this thread) as a hard use folder should be an insult to common sense. My conservative guess would be that the lockstrength of the RAO is easily 4 time as high as that of the Strider framelocks and even then they felt the need for a safty pin. I wonder what a 1/4" blade is going to buy you, if the rest of the folder is not up to par? (In general, lock reliability is clearly more important than ultimate strength, but with a 1/4" thick blade you stake a certain claim on strength, that the lock should be able to back up, I think).