Hate to disagree with Dorito but NO you don't need cut out's and their called relief cuts. I have a custom made STR (Steve Rice) Heman ti framelock no relief cut, at my request. My thumbs are not that strong and I can get it done no problem. I also have a few Mission MPF 3 which have a relief cut out of .0850 damn near a tenth of inch and I can handle those no problem.
Yes it does weaken the lock, try this. With the knife closed take your finger and put pressure on the top of the lock bar face essentially trying to push the lock bar down to the bottom part of the handle, where the line has been cut horizontal down the handle to allow the lock bar to slide over. If you can press it and get the bottom of the lock bar to touch the top of the bottom part of the handle, you ain't got much.
Lastly to the poster saying most liner locks are are as thick as the relief cuts, you haven't spent time with a digital caliper and handful of folders both liner lock and frame lock. Because while in some instances it may be close, most of the time I find the liner locks to be thicker than the relief cuts. Moreover steel is stronger than titanium, so the comparison of just thickness doesn't work as you would have to a much thicker titanium lock (relief cut) to be as strong as a thinner steel liner lock.
Look I like titanium frame locks, that is my preferred knife but I'm very picky about what I'll get because of relief cut thickness. There a lot of "hard use" folders out there that if someone sold me at that price with a relief cut that thin, I demand a refund. I've seen knives with relief cuts that are like 0.0200 of inch thick, or really should I say thin. One other thing titanium is a notch sensitive material so it responds better to long cuts as opposed to short ones, so relief cut thickness should be increased and also lengthened. I suspect their thin and short to save manf cost and to allow for the easiest opening and closing of the knife as possible.
My theory is most of these hard use knives floating around are either safe queens, or pocket queens with people babying them because they cost so much they don't want to mess them up. So you not going to see any real number of lock failures as people simply are not really using these knives much, carried alot, used little and gently. Now there are going to be some exceptions without question I know some of you are just beating the hell out of these things 24/7 in the depths of mortar and its never failed and the lock up is even earlier than when you got it, congrats on being the exception.
Just saying the whole ain't gonna happen thing, happens everyday for me. It's a matter of personal preference, it can and is being done.