Won't help you OP but I'm ambidextrous.
I shoot & write left handed and play sports & hold knives right handed. So, the right hand bias of most folding knives isn't a problem for me. However, there are a variety of knives that are ambidextrous or made specifically for left handers.
I started collecting knives w/cheap Kershaws and CRKTS and then moved up to move expensive ZTs and Spydercos. Also collect Benchmades, MicroTechs, Protechs, Cold Steel and a few other brands.
I wouldn't say that I wasted $ on the Kershaws and CRKTs. Collecting them laid the groundwork to buy the more expensive ZT/Spydercos (and other knives) by making clearer to me what kind of knives I liked best and what things to look for in "better" knives. This was a learning process and something that will not come to you overnight.
I still have all of the Kershaws/CRKTS that I bought early on and do not feel compelled to sell them because they didn't cost much, are still useful and I wouldn't get much back for them if I tried to sell them. So, why bother? I am also buying more of them; I'm just more selective about it now than I was before.
You can also feel freer to make buying mistakes at the $20-50 level than you would (unless you're well off) at the $100-200 level. However, if you want to buy just 1 good knife, Spyderco makes a left handed version of the Para Military which always tops various knife buying lists as one of (if not) the "best EDC." They also make a left handed Military but that's probably more knife than you'd want to carry as an EDC.