I'll just put in my .02 as a lefty myself I personally have found right handed knives to work as well or better for me the only thing ever "needing" changed is usually the clip location but that doesn't matter much. I have found for majority of knives using holes the hole is accessible from either side making it relatively ambidextrous and flippers are all ambidextrous. What often is the real "lefty" piece is the lockbar for me personally I prefer having a right handed lockbar and then the clip as it relates to how the knife rides in pocket and how you will grab the knife from your pocket. For my the clip is largely irrelevant as there is more than one way to grasp and pull the knife from your pocket which can adjust for a less desired positioning in the pocket. So for my unless the opening mechanism is only accessible when gripped in the right hand, technically still accessible just awkwardly left handed, I tend to view most all knives as ambidextrous. The final issue would be chisel ground blades as cutting with the left vs the right hand would dictate which is the "back" of the blade and a chisel grind only have 1 back making them specifically left or right handed.
