I'm a huge Spyderco junkie, so I have at least one Spydie on my person at all times (except while in the shower). I tend to pick up a new one every 2 weeks or so (or every week) so it's usually the newest one riding in my pocket. You can't really go wrong with any of their offerings, but my all-time favorite models include:
Yojimbo
Endura
Military
Manix
Rescue
I'm just now getting into the Salt (H1) models, and I really, really like them so far. There's a lot to be said for a knife that is flat-out incapable of rusting. Living in super-humid Georgia, and having a LOT of knives, I spend a good deal of time oiling my blades to keep them from rusting. The Salt knives you can clip into your swim trunks and go swimming and never have to worry about rust. Pretty cool. I like the Tasman Salt the best so far, it has a wicked hawkbill blade on it that cuts like nobody's business. It's basically a FRN Harpy.
I like Benchmade a lot, too. I've recently decided on the 940 as my all-time favorite. Though the 806, 710 and Rukus are excellent as well. I thought I loved the new Nitrous Stryker, but the D2 blade rust ridiculously easily, even when oiled. The Nitrous Stryker in 154-CM would be amazing. Uncoated D2 is a bad choice for a folder steel.
I can't wait until it gets cold enough that I can wear a jacket. I really want to EDC my AD or my Warden, but haven't figured out how to conceal them yet.