I carry an HK USP Tactical chambered in .45 whenever in the woods hunting or not, the woods here are thick we have a very serious venomous snake problem, pig problem in many areas, bears are also making a huge comeback and lets not leave out the occasionally cougar or mountain lion whichever you want to call it.
I had a big cougar come into my opening day of muzzle loader setup about 4 years ago and put the smack down on one of two yearlings that was with a big doe at about 20 yards. HOLY, @#$#$@#, I had to walk out of the palmettos and briars that were chest high with only a one shot muzzle loader. Never went back without a pistol, EVER and won't that cat could roll a grown man with no problem after I saw it just destroy that yearling and it weighed a good 80lbs and that cat just utterly annihilated that thing, it was awesome and incredibly scary at the same time. If one hit you from behind or from the side in thick brush the only chance you would have it with a pistol and that is if the thing doesn't hit you so hard it doesn't knock you out.
One of the most disturbing things was through the thickest woods the thing didn't make a sound. I watched it sneak from about 5 yards away from the deer after I spotted in through a hole in the palmettos I was watching, NOT A SOUND, those deer who are pretty alert creatures never knew it was there.