One use where it's easy to hurt yourself is processing large game. I can and have done it with a slip joint. A lockback might provide a little more safety. Still a fixed blade is safer and much much much easier to clean as you don't have joints to clean the meat out of.
IMO, there are 3 specific movements where I think a lock provides real added safety:
Stabbing - In a stabbing or piercing cut, a lock helps prevent the blade from closing. When cutting meat, these closing forces are well inside of the range that a decent lock can withstand. Stabbing harder materials, like drywall (or tough hosing, ahem), may exceed the force the lock can withstand.
Withdrawing - In some cutting tasks it is possible for the blade to stick which requires force to withdraw. This can create closing forces on the blade. When freeing a knife from meat or game (like dealing with joints or ribs) or dealing with frozen food, I think those closing forces are generally well within the ability of a decent lock to withstand. In tougher materials like wood it might be possible to overcome the lock in this way.
Bumping - When working with a knife on a long task, it sometimes happens that I bump the spine of the blade as I'm working, especially when making repeated drawing cuts as in skinning or clearing out brush. These bumps can create closing force on the blade and in most cases, a decent lock mechanism will withstand these forces just fine.
I don't know of a single knife knut who prefers to use a locking folder over a fixed blade.
But the reality for me is that I'm almost never in a social situation where carrying a fixed blade is feasible. I can EDC a locking folder like really, every day.
When the practical choice narrows down to slip joint vs a locking folder, I find the locking folder to offer a real safety advantage in the above situations. Note... as with any risky behavior and related safety gear... It's incumbent on the use to access the risk, to understand the limitations of the safety gear and to understand how over-estimate the safety benefit can actually lead to more risk. This is seen repeatedly in the use of climbing helmets, crampons, avalanche beacons, ice axes, bike helmets, ski helmets and yes, locking folding knives.