As a right-hander I’ve recently purchased a few left-handed 21s that were harder to find in RH configurations, and have been very happy with them. I’m not ambidextrous but they’re not that difficult to deploy. I think it makes sense to have one in the event your right hand is otherwise unable to reach and/or operate your regular knife. If I find a CRK I really like I get it regardless of its ‘handedness’.
Allan