In my use and experiment the best option comes from some form of coarse edge overlayed with the finest abrasive you have - or at least one that is MUCH finer than the one used to create the initial cutting edge.
This allows you to do two things, one is the initial edge can be very coarse for rapid edge reset. It also sets the baseline for any along-edge irregularities you might want to help with draw cutting.
Moving to a much finer abrasive at a higher angle has the effect of laying in a less acute but thinner edge across the apex with fewer irregularities - it is more durable. How many passes you make with the finer abrasive allows you to customize the amount of tooth etc without needing that "just right" stone grade.
There are some limits to this if there is a particular edge finish you have in mind it might make sense to use a progression to reduce any irregularities, say for a woodworking tool. For a kitchen or pocket utility edge normally only two grits are needed and you end up with a great all-around finish. It also requires very little tinkering with the specific plates, stones etc that you might be using eg going from XC DMT to an EF you can get a very predictable repeatable edge.
The downside to this is it takes some practice freehanding a shift of only a few degrees per side, but not too tough. On a guided system it couldn't be easier.
I've tinkered with it a bit lately, after reading the above, and found that^ to be a very good strategy.
I used the XC DMT to set a fairly acute (sub-30° inclusive) edge on a Lightweight Buck 110LT in 420HC, then followed with a microbevel done in just a few extremely light passes on a Spyderco Fine ceramic (using the 30° setting on the Sharpmaker). The intended goal and result being, the 'microbevel' is so 'micro', it's not even seen by the eye, but it's effects on cutting become very obvious, very quickly. The microbevel's finish, left from the fine ceramic, is just enough to thin the apex AND clean up any coarse burrs or irregularities left by the XC diamond, leaving the edge hair-popping, as I'd expect from the fine ceramic, but still retaining some vicious, sticky bite, as I'd hope to see from the XC diamond. And using a pseudo-guided setup like the Sharpmaker, for the microbevel, makes maintaining the angle less daunting than if done while still trying to learn a freehand touch. All in all, it's a great strategy toward a wickedly aggressive edge, AND it's very simple to do.
Since I'd bought that Buck, I'd been looking for a favorite means to apply an aggressively toothy edge on that thinly-ground blade, which Buck does well. It just seemed like this particular knife really wanted for such an aggressive slicing edge. And so far, that XC diamond + fine ceramic combo is impressing me.
