The situation that comes to mind, regarding profiling and heat treating multiples, is if you drill holes for pins/bolts, ensuring they are a really nice fit...then heat treat, and all the holes shrink. Now you have however many holes x multiple blades and the fun job of opening holes in hard steel, or down-sizing the fixings.
If you make hidden tangs, I think there is a lot less risk in taking several blades to a heat treated stage. You have not tied yourself to a handle shape.
Hubert S,
I certainly do hear you with your video game analogy. Maybe my different perspective comes from having made my first 12 or so knives without the benefit of power grinding or power cutting. It is much harder to "die" and be thrown back to first level when you are hand filing and hand sharpening on a stone. I timed making one of those early knives (morticed tang, wood handle, 6" blade in O-1 with brass double guard) and I spent every spare moment, and let all domestic chores go hang, for two weeks. That sort of time investment per knife increases the risk of making multiples when you are starting out with the designs. Three of the earliest were heat treated by someone else, as a batch, and I made the same mistakes on all three, which meant that after completely finishing them they went in a box never to be used.
My last batch (14 assorted), made with the benefit of power, presented another situation, by the time I had finished a few of them, my ideas about the ideal design had changed. Finishing the rest means performing remedial corrections rather than just finishing as originally intended.