BTW, I realized on Thanksgiving week, that this is a month or 2 late, but figured it might be worth considering, for the upcoming Christmas get-togethers (hopefully, no one had a case of a relative/friend doing the, "I'm sick as a dog, but CAN'T miss Thanksgiving! So what if I get EVERYONE else sick, too?")
If anyone hasn't yet gotten their flu shot, but is thinking about it;
For the folks genuinely interested, here's some data: to look through
1a) circulating strains this season
https://www.google.com/url?sa=t&source=web&rct=j&url=https://cdn.who.int/media/docs/default-source/influenza/who-influenza-recommendations/vcm-southern-hemisphere-recommendation-2023/202209_recommendation.pdf?sfvrsn=83a26d50_3&download=true&ved=2ahUKEwjjq5OE2sT7AhVjATQIHVi4BZ0QFnoECBMQAQ&usg=AOvVaw2bF2Pc5irXBPgarYTUYy52]https://www.google.com/url?sa=t&source=web&rct=j&url=https://cdn.who.int/media/docs/default-source/influenza/who-influenza-recommendations/vcm-southern-hemisphere-recommendation-2023/202209_recommendation.pdf?sfvrsn=83a26d50_3&download=true&ved=2ahUKEwjjq5OE2sT7AhVjATQIHVi4BZ0QFnoECBMQAQ&usg=AOvVaw2bF2Pc5irXBPgarYTUYy52
1b) circulating strains in the US
https://www.cdc.gov/flu/weekly/fluv...www.cdc.gov/flu/weekly/fluviewinteractive.htm
2) vaccine response effectiveness (summary: Sanofi's recombinant flu vaccine 'Flublok' has shown to elicit significantly higher CD4 T-cell response. Walmart is one chain that carries it)
https://www.nature.com/articles/s41541-020-00227-x#:~:text=By this measure, 78% of,exhibits the highest vaccine efficacy.]https://www.nature.com/articles/s41541-020-00227-x#:~:text=By this measure, 78% of,exhibits the highest vaccine efficacy
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I have no affiliations with any of these companies.
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P.S.
PCR confirmation is showing that both H3N2 and H1N1-pdm09 are currently circulating in the US, with H3N2 accounting for ~3/4 of confirmed Influenza Type-A subtypes. In my AO, H1N1 has been on the uptick (VE against Type-B influenza is typically very good, but Type-B flu is currently only accounting for <2% of typed cases in the US).
Generally, flu vaccines have demonstrated very good VE (Vaccine Effectiveness) against H1N1-pdm09 variants (typically between 75% to 90+% VE, and have been included in the vaccine every single year since H1N1-pdm09 first emerged in 2009), even when there are some differences (mutations from antigenic drift) between the circulating type vs the CVV (Candidate Vaccine Virus).
Egg-based flu vaccines have shown significantly lower VE against H3N2 (30% - 40% or lower), as the specific mutations known as 'egg-based adaptations' negatively impact the VE against H3N2 significantly more than against H1N1.
For higher VE against H3N2, I would specifically look for either Flublok or Flucelvax (Flublok is a recombinant vaccine. Flucelvax is a cell-based flu vaccine. Neither one produces the egg-based adaptation mutations that have been shown to reduce VE against H3N2).