Random Thought Thread

That Quartzite kitchen island counter must have weight half a ton.

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Interesting to see how they glue two pieces together:

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And yes, I need a hair cut.
 
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beeinak said:
If you think it is the actual flu, get swabbed and treated. Can really reduce the time to feel better!
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50% reduction in time of clinical symptoms (if oseltamivir started within 24 hours of symptoms) mentioned here: https://pmc.ncbi.nlm.nih.gov/articles/PMC2840043/ doesn't really fit with my clinical experience. Seems more like it cuts about a day off (reducing biases like this is why we do the research). Reduction in mortality in higher risk folk, though, is not to be ignored. At least it doesn't make your mouth taste like an entire tribe of asphalt soaked baboons are living and shitting in your mouth for a week, like Paxlovid (for COVID) does.
 
fnordmorph said:
50% reduction in time of clinical symptoms (if oseltamivir started within 24 hours of symptoms) mentioned here: https://pmc.ncbi.nlm.nih.gov/articles/PMC2840043/ doesn't really fit with my clinical experience. Seems more like it cuts about a day off (reducing biases like this is why we do the research). Reduction in mortality in higher risk folk, though, is not to be ignored. At least it doesn't make your mouth taste like an entire tribe of asphalt soaked baboons are living and shitting in your mouth for a week, like Paxlovid (for COVID) does.
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I noticed a difference with treating my patients and with taking it myself- obviously my experience may not correlate to other findings. The last time I had the actual flu I felt like absolute crap and told my wife that if I wasn’t feeling any improvement in 24 hrs, to dump me in a snow bank and leave me there🤣.

Your description of the Paxlovid after-taste should be listed on the infomercials! Very descriptive!
 
fnordmorph said:
50% reduction in time of clinical symptoms (if oseltamivir started within 24 hours of symptoms) mentioned here: https://pmc.ncbi.nlm.nih.gov/articles/PMC2840043/ doesn't really fit with my clinical experience. Seems more like it cuts about a day off (reducing biases like this is why we do the research). Reduction in mortality in higher risk folk, though, is not to be ignored. At least it doesn't make your mouth taste like an entire tribe of asphalt soaked baboons are living and shitting in your mouth for a week, like Paxlovid (for COVID) does.
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Do tell....
 
fnordmorph said:
50% reduction in time of clinical symptoms (if oseltamivir started within 24 hours of symptoms) mentioned here: https://pmc.ncbi.nlm.nih.gov/articles/PMC2840043/ doesn't really fit with my clinical experience. Seems more like it cuts about a day off (reducing biases like this is why we do the research). Reduction in mortality in higher risk folk, though, is not to be ignored. At least it doesn't make your mouth taste like an entire tribe of asphalt soaked baboons are living and shitting in your mouth for a week, like Paxlovid (for COVID) does.
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Since the neuraminidase inhibitors basically function by interfering with the viruses replication cycle, their effectiveness is dependent on the patient’s/subject’s immune system, and the viral load.

If the viral load is already high, it’s kind of like blowing up the bridge after most of the invading army has crossed over.

What makes sense to me, is taking it in prophylaxis, but the use case scenarios are impractical.
A) you would need to have it on hand, and start taking it when someone in the household tests positive for influenza
B) just because someone in the household is positive for influenza doesn’t guarantee that another family member WILL fall sick with it. Differences in immune systems and prior exposure all play a part, so if you take it in prophylaxis and don’t get sick, was it because of the antiviral?

If there’s an immunocompromised/elderly person in the household, THEN it makes a lot of sense to keep it on hand to take proactively if someone else in the household tests positive.
 
bluemax_1 said:
Since the neuraminidase inhibitors basically function by interfering with the viruses replication cycle, their effectiveness is dependent on the patient’s/subject’s immune system, and the viral load.

If the viral load is already high, it’s kind of like blowing up the bridge after most of the invading army has crossed over.

What makes sense to me, is taking it in prophylaxis, but the use case scenarios are impractical.
A) you would need to have it on hand, and start taking it when someone in the household tests positive for influenza
B) just because someone in the household is positive for influenza doesn’t guarantee that another family member WILL fall sick with it. Differences in immune systems and prior exposure all play a part, so if you take it in prophylaxis and don’t get sick, was it because of the antiviral?

If there’s an immunocompromised/elderly person in the household, THEN it makes a lot of sense to keep it on hand to take proactively if someone else in the household tests positive.
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It's one of those things that you need to already have on hand because getting an appointment and then going to get it takes about a day.

Anti nausea medicine and steroidal anti-inflammatories are kind of the same way too. IMO
 
Nathan the Machinist said:
It's one of those things that you need to already have on hand because getting an appointment and then going to get it takes about a day.

Anti nausea medicine and steroidal anti-inflammatories are kind of the same way too. IMO
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Yup.

I wouldn’t put anti nausea meds in the same category, though. Although it’s obviously better to have them on hand to take them early, they still work even with the delay.

With things like neuraminidase inhibitors, their effectiveness decreases the longer the delay.
 
Nathan the Machinist said:
It's one of those things that you need to already have on hand because getting an appointment and then going to get it takes about a day.

Anti nausea medicine and steroidal anti-inflammatories are kind of the same way too. IMO
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That is why kits from The Wellness Co have been selling like hotcakes. Nice to have on hand and hope not to need.
 
Blues said:
What are they charging for that kit, B? Those are the ads with Dr. Drew?

I'm taking my medicine right now. A dram of Laphroaig 10 as payment for putting up the Xmas decorations for the boss.
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Dr. Drew is one of the promoters. They have different kits with assortments of different meds, along with varied prices. None are cheap- but cheaper than an urgent care visit deductible for many. Also convenient to have on hand if you are far away from healthcare or pharmacy (or to have while hunting/fishing/camping/traveling).

Keep the boss happy!
 
beeinak said:
Dr. Drew is one of the promoters. They have different kits with assortments of different meds, along with varied prices. None are cheap- but cheaper than an urgent care visit deductible for many. Also convenient to have on hand if you are far away from healthcare or pharmacy (or to have while hunting/fishing/camping/traveling).

Keep the boss happy!
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I just looked. About $300. (My urgent care is $35 this year, no deductible, going up to $50 in 2026. No deductible.)

ER is more...$200 copay...deductible waived if accidental injury...(copay waived if admitted to hospital)

If not an accident but a medical emergency, then $200 after deductible. If admitted, copay is waived.
 
beeinak said:
Dr. Drew is one of the promoters. They have different kits with assortments of different meds, along with varied prices. None are cheap- but cheaper than an urgent care visit deductible for many. Also convenient to have on hand if you are far away from healthcare or pharmacy (or to have while hunting/fishing/camping/traveling).

Keep the boss happy!
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To Me, it sounds like All of you need to eat way more garlic, and ginger
 
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