I think the Native III is one of the 'better' Spyderco designs. I don't mean just either aesthetically or ergonomically.... far from that.
I mean for its price point, materials, ergo's etc... it represents a great blade, from a great company using good materials at a price that is good for people who need a nice EDC that can do the job well.
IMHO.... I think the 'fatter' handles on the Native III feels better than the I or II, but the fact that the Spyderhole does not fully present itself to your thumb (some sort of mating ritual between thumb and hole

) means you have to get your fat thumbs pushed further in between the handle and the 3/4 hole.
The only thing I do not like about the Native 3 is the wire clip.