I picked up one of the 420HCs a few months ago. I would have gone with the CX, but that darn combo edge stopped me. For my purposes, it's been great. I don't usually wear a belt, and I don't like carrying very much in my pockets, so I didn't want to lug around a bigger multi-tool and a separate knife. I needed something light with a belt clip that had a one hand opening blade. I'm just a software developer, so I don't really need a huge assortment of tools everywhere I go, but the skeletool has enough to get me through the occasional tool-requiring job.
A couple of the dislikes for me (mostly minor):
From the factory, there was no way that it could have been considered a one handed opener. I had to take it apart and get rid of a couple burs and work it in for a half hour before it started to smooth out. Even now that it is pretty smooth, it's a bit awkward for me to open it with one hand. I have to choke up on my grip to open it, and have trouble when my hands are wet at all. I would have preferred a stud to the small thumb-holes.
The blade itself is thicker than I would normally use for its' size. Since it's the only blade I carry anymore, I guess I shouldn't be complaining that it's sturdy, but there have been a couple of finer tasks that I wished I had a thinner knife for.
The screwdriver and pliers are ok for quick tasks, but for extended use, I find the screwdriver to be really awkward to use and the pliers to quickly get uncomfortable (using a sog powerlock as a comparison). A bit extender so that the screwdriver could be used while the unit is closed would have been great, but I don't see how they could have fit it in. The bottle opener works great, but I have chipped a couple of bottles when not being careful.
For a light use EDC, I really really like the skeletool. The couple of issues are far outweighed by the fact that it's a package that I'm actually willing to carry all the time. However, as mentioned by the previous posters, if you are looking for a hard use multi-tool that you can use all day, I would look elsewhere.