I use premium when I can (local station didn't carry it for a while when gas was pushing $4 here - local means within 50 miles

), also use a steel gas can - plastic breaths and your fuel turns to varnish if left more than a few months.
The thin, dry air around here is really hard on 2-cycle engines, or any air cooled engine really. After seeing many local guys going through a saw in 3 years or so under moderate to heavy homeowner use (not pro use),
I started running 32:1. Seems to help, I don't have any of the compression problems I see with neighbor's saws (and no one's worried about a bit of blue smoke out here - that 50:1 deal is for cities in my book).
EDIT:
I may have to look for some of that Tru-Fuel. Seems expensive, but if it helps your vastly more expensive equipment last a lifetime, then I figure you're ahead.