As a lefty, I have always regarded the compression lock as ambidextrous. For one-hand closing, I close it similar to the way I think many people probably close a backlock -- just depress the lock tab with your thumb and catch the choil with your middle finger (forefinger if right handed), then close with your thumb, pants leg or whatever. I don't see any problem with that. Of course, if you're right handed, you can more easily depress the tab with your fingertip and swing the blade in with one action. But if you like, you can grip the handle with all four fingers and depress the tab with your thumb like a backlock. Like Roman says, I think it is a matter of habit.
I think it will be a great knife but I also believe it is too different to characterize as a member of the Native family; there's more differences than similarities. I still look forward to trying one when they arrive. I hope you can overlook the compression lock and find enjoyment in the knife just the same. Best wishes.
