For everything other than winter hiking/snowshoeing, I've mainly gone with low cut hiking shoes. I've tried very hard to pare my pack weight to about 30 lbs or less and I felt that I didn't need heavy boots anymore. I've had the best success with Scarpa approach shoes with a Superfeet insole. They can be a challenge to find though. My pair of Merrell hiking shoes wore through at the heel but other than that they are some stout shoes. I feel really confident with them as they are a really stable platform. I tried a pair of Lowas but they were too wide for my feet.
I've found that my ankles are stronger from hiking in lighter shoes. If I was lugging around 40+ pounds on my back, I'd go for some over the ankle boots, but I feel good in the lighter shoes I've had. I don't feel like I'm hoisting cement shoes at the end of a long hike anymore.
As for goretex, it's everywhere. I don't think it's necessary at all on leather boots if you treat them with something like Sno-Seal. I find that my feet sweat a lot so my feet get wet no matter what I do. I just change my socks more often (SmartWool mostly).
Lastly, I can't say enough about good aftermarket insoles. I know it's hard to spend $30 on insoles when you've laid out a chunk of cash on shoes, but most insoles that come in the shoes are garbage. Flimsy, no good stuff that may or may not work for you, but the Superfeet ones I have in lots of my shoes give me a solid platform and they seem to keep my heel in place. Try some out even if it's in the store while you walk around and look at cool lightweight cook sets and ferro rods.
Oh, and I forgot to mention that in wet conditions my gaiters work fine with low-cut hiking shoes.
Whew! I'm done.