Regarding G-10:
When knife-knuts read G-10, they immediately think durability. It's tough, grippy (if patterned correctly), resistant to solvents, and usually found on knives with precision construction and lockup.
Kraton is more commonly associated with full molded handles on cheaper knives. Solvent resistance can be an issue, particularly with DEET-based insect repellents and gasoline, etc. Although there are some knives out there using Kraton, most aren't higher-end items that people specifically seek out (as opposed to going down to Walmart and seeing what they have in stock). (a notable exception is the Swamp Rat line, but I think many people are drawn to those as an affordable Busse)
So kraton inlays might not perform badly, but they do have some negative perceptions associated with them. You'd likely have to get the knife into someone's hand to change these perceptions.
I'm with Carlos on the weight issue. A 3.5" blade with steel handles is probably going to be a tank. Keep the weight down, whether by slimming the handles or using aluminum.
Regarding color:
Black and various metal-grays tend to be dominant because they don't turn off many people, whereas a particular color can provoke a strong reaction. Some sort of bright color would be useful for retrieving knives lost in the woods, but I think that it would have to be aggressively marketed to hunters/fishers to make it worthwhile, particularly if that color was blaze orange. On the other hand, a blaze-orange insert might appeal to construction workers and the like looking for a tough utility pocket knife. You could play up that angle by stressing the knife as a safety tool - cutting clothing that got caught in machines, for example.
Finally, YAY BIG HOLE!!!!!
