Well in the world of Spyderco I have decided on either the Native 5 or Sage 4. But there are other manufacturers that I may consider as well.
Both good options. One quick suggestion - if you're partial to titanium framelocks, take a look at the Sage 2. I had that and a small Sebenza and gave up the Sebenza in favor of the Sage 2. It's more ergonomic, has higher hardness blade steel and has the titanium handle that so many of us cravve.