I'm going to go with "What is personal preference in an EDC?" for .02...although I'm a big Spyderco fan, I just purchased my first Millie, it's the "1.5" version. My reaction pulling it from the box was that it's too light to be a real knife. I prefer the mass of my 20 year old all stainless Endura. Another example: one of my EDCs is the Gayle Bradley 1, with the non-skeletonized liners. I recently had a GB 2 in for a couple weeks, and I was able to hold both (the GB 2 was not my knife, so I couldn't use it, but I could still get an idea). The GB 1 just felt better in my hand.
I think part of my preference comes down to something I'll call "micro-control". My hands are pretty messed up from strongman competition, and they're not the most steady. A light, rigid knife tends to more effectively transmit all those "micro-motions" directly to the cutting edge; a heavier knife acts as a bit of a dampener, so when I'm making a more precise cut, the bad motions of my hands don't totally screw it up.
As far as the carry weight: at 6' and 265 (my out of shape weight; if I'm in competition shape, my weight is about 310lb), I don't notice a few ounces here or there.