1) Strider SMF. It is not only the most comfortable knife I have ever held overall, but also the most comfortable in every single grip other than whittling. Well, maybe not "comfortable" in a cushy sense, but a combination of comfort and retention. Security! The G-10 is the best I have felt. I like it very rough.
2) Spyderco Manix. Just a bit behind the SMF in every grip. The G-10 isn't as good and it lacks the big notches the SMF has. The overall shape is slightly inferior for retention and comfort. Overall, though, it is fantastic.
3) Benchmade Activator. It is small but fits my hand like a glove in the standard grip. The finger cutout is in the perfect spot for my hand and the notches on the spine work well and extend out far enough to grant grip to the index finger while in the whittling grip.
4) Buck Mayo TNT. The little lips on the top edges of the handle near the pivot work great as thumb and finger ramps. The holes in the frame offer great grip. Being so light aids the comfort as well.
5) Buck Short Nighthawk. Kraton in the right places. A great thumb ramp. Grippy and fills the hand.
Honorable mention to the Rukus and SERE 2000. I think the RUKUS is slightly too bulky, and the thumb ramp on the SERE 2000 is too slick.
The Military feels good, too. I think it feels great choked up, but a little lacking when I want my index finger to be further away from the choil.
Edit: I forgot about the Kershaw Spec Bump (probably since I do not own one yet so it wasn't on my mental "knife list"). I have handled the old and new models and find them both to be fantastic, though I prefer how the G-10 feels on the newer model. An S30V Spec Bump is probably my next knife. Fits my hand like a glove. The titanium Bumps are great too. If I were to stick the Spec Bump in on my list it would be 2nd or 3rd.
Edit 2: I also forgot about the Dodo (again, probably because I don't own one yet). But a blue Dodo is also on my to buy list, and I have also handled one. I'd put it right behind the Spec Bump.