With all of the ill-will that some people have had for the Axis lock and Benchmade in general, trust me it's been tested.
There was some scuttlebutt a year or two ago about the thumb being able to unlock the knife on a very specific self defense stabbing motion but I don't believe it was ever substantiated.
depends on what ya mean by substantiated,that was by chris carraci the guy who designed the AFCK for BM, ex SEAL/etc, used to have a forum on bladeforums, dont remember what happened to him, too busy IIRC to fool with it, he claimed that in a fight the button could be accidently moved releasing the lock, i have looked at my axis lock knives and though i dont think its likely, i guess it COULD happen, he said the std AFCK was a better combat knife vs the axis AFCK, this was a few yrs ago he might have changed his mind, or maybe not.