Manix 1 full size. It's big, powerful, ergonomic and a wonderful cutter. I know of no other folder this size that cuts this well. If I changed anything, I'd use a more exotic steel -- like M390 or M4 or 3V -- and put in a larger pivot. It probably doesn't need a larger pivot -- I trust Spyderco on that -- but it just looks like it would love one.
Military Ti/M4. Wonderful design and a great steel with an excellent heat treat. Excellent, full flat grind cutter with a slim edge. Slim and easy to carry. Best execution of Spyderco's flagship.
Military Ti ATR plain edge. Best execution of the compression lock. Extremely smooth. Big and strong. Sexy. The cobra-head flipper just works in this design.
Lava, which has the best ergos of any small knife I've tried.
I would have included the Gayle Bradley because of the wonderful blade, but the hokey shrunken scales and the lack of recess for unlocking makes it too flawed in unmodded form.