What is "best" is completely subjective when we discuss pocket knife locks. I think the question should be "What lock do you like best?"
It is hard for me to say what lock I like best. I like most of them quite well, so long as they are done correctly, accomplish the task (locking), and the knife they are attached to is befitting a quality lock up. Most of them have their plus and minuses to me. For example, I love the axis lock but the weak detent always worries me. Frame/liner locks are a bit awkward, force you to but a finger in the direct path of the blade and are the easiest to mess up in making, the compression lock can be pinchy, and the back lock can be stiff. Slip joints don't even lock at all!
I still own and love all those locks though. I guess it is more about the knife than the lock, another example, the collar lock on the opinel seems pointless to me. Might as well be a slip joint or a friction folder. I think I use the back lock the most, as I have a Pacific Salt on me most of the time. Well, unless you count the slip joint lock on a SAK. I use that a billion times a day.