Comparing a 1/8" blade to a 1/4" one is quite extreme.
Perhaps, but I doubt 3/8 will cahnge picture significantly.
However, as Jim said in an earlier post, thickness at the spine cannot explain everything.
So did I

And in some cases even blade grind won't matter, e.g. manila rope or rubber under tension, because only the edge comes in contact with the medium. Although, that's not a good reason to ignore blade grind altogether. Same applies to the spine thickness.
Look at these two knives:
The Ryan has a slighter thicker blade than the AFCK. Which one do you think is the best slicer, and which one has the strongest blade?
AFCK is a better slicer given equal edges. Longer blade, narrower too. Grind transition on the Rays will increase drag and resistance to cutting. I.e. the user or operator has to use more effort.
Don't take my word for it, try to cur thick piece of cheese, rubber, or something wider than Rayian's blade...
Obviously Rayan has stronger blade, and I do like how it looks, but even if I had it, it's unlikely I'd use all that strength in my uses.
To avoid usual misunderstandings, I do not question that knife can cut "well" for its length, when properly sharpened, and I don't doubt it will cut everything AFCK will, and then perhaps some other things including prying in which AFCK will fail earlier.
However, I'd have to use more force, and more movement to accomplish the same amount of the work. Which is the only argument I have against thick folders, in context thick vs. thin.