I'm not gonna bother to read everyone's response rather I'm just gonna answer the OP.
If it comes apart, I take it apart especially when BNIB, than again I'm a mechanic/machinist/millwright by trade and ever since I was able to hold tools have taken everything apart from legos and hot wheels to real houses and real cars. If you have the knowledge and the correct tools there's no reason not to take it apart. I've taken apart every Spyderco I own that came apart from the very first Spyderco that came apart to my OTF, coil and leaf spring autos. Blue removable to red permanent Loctite doesn't matter and I have sent knives back for warranty work and never had an issue because they never knew it was taken apart as it should be.
Like I said earlier, if you have the knowledge and the proper tools there would be no indication of previous disassembly. Even if they have tamper proof screws or use tamper resistant protocol if you know what you're doin' they'll never know you took it apart. If your that good then there's probably no reason to send a knife back anyway.
The main reason I take them apart too is to see what it looks like when it's new with no wear, missing or broken parts, this goes a long way in diagnosing problems and recognizing worn parts.
With all that bein' said, Sal has a right to Loctite the screws to prevent disassembly in order to keep from increasing the price point of an assembled finished product due to the cost of operator/owner incompetence while attempting service or repair when they clearly haven't the knowledge or skill set to do so. On the flip side of the coin is CRK who because of such tight tolerances and top notch QC encourage their owners to disassemble their knives even to the point of including the "proper" tools to do so.
Back in the 80s Buck had a great idea, they took one of their best selling knives and changed the platform to one of being able to be disassembled by the owner and like CRK several years later Buck even included the tool to take it apart and used that as a selling point in their advertising. Their tolerances and use of bushings in the pivot for the blade and the backspring lockbar made the assembly pretty much idiot proof but we all know when you make something better by making it idiot proof, better idiots evolve. Within one year Buck lost so much on service and warranty work because of the inability of enough of the owners to properly assemble an idiot proof knife they discontinued the titanium model 186 renamed it the 560 and permanently riveted the knife together solving a big problem on an otherwise cutting edge knife and cut their losses. BTW it also made the original 186 a highly sought after and collectible knife.
