Funny, I took out all my knives yesterday to see which were feeling best in my hand. I've bought around 6-7 knives in the past few months and haven't really put my selection head to head in a while. Firstly, different designs call for their own unique grips & this can't be ignored or bypassed. Secondly there is a significant difference between sitting on the couch, squeezing a handle, vs. carving wood or something like cutting hard plastic or rubber. Plus there are different grips/techniques with different tasks. The most comfy by far is my Fiddleback Forge "Paring Knife" but that's a fixed blade. As far as folders go, my Lg Seb 21 leads the pack followed by a Knives Of Alaska Folding Hunter. SnG certainly is up there but I'd prefer the jimping to be less aggressive. The least comfy knives I have are the Microtech Socom Delta (the clip is in the way for me) & a Hogue EX01 (all around uncomfortable for me). I have XL hands though & my buddies that do dig knives both really dig these two.