I always carry my primary EDC on my front right pocket and a back-up on my right rear pocket, either a Kershaw Leek, or a Kershaw Junk Yard Dog. I've never had a problem with any of my back-ups being uncomfortable riding on my back pocket, whether wearing jeans, or slacks. Never any weight issues either; my wallet weighs more than my knives. IMHO the only thing to watch out for while carrying on your back pocket, is to make sure that your pocket clip doesn't easily snag on chairs, sofas, etc., as it could pull your knife off of your pocket when you get up. I've had it happen with both a Mini Cyclone, and a Junk Yard Dog.
Good luck.:thumbup: