Good perspectives in this thread.
I agree with LVC that Resiprene can be vulnerable to splitting, but after seeing what the handles on Noss's test knives went through, as LVC also says, it's hard to imagine damaging a Resiprene handle to the point that it's not useable. And even though micarta is obviously much tougher than Resiprene, the tube fasteners securing the micarta slabs on Busse knives can be broken by impact (also shown by Noss in his FFBM test), and once the fasteners fail you're down to a bare tang for a handle--no more appealing than a damaged Resiprene handle, at least in my mind.
I also once thought the full-tang standard Busse construction would be much stronger laterally than the reduced tang encased by Resiprene on the Basics, but there again, from Noss's testing on the Basic 9 and the Scrapper 6 it appears that the tang length is short enough in proportion to the blade that the flex point in terms of lateral loading remains out on the blade. In fact, the only reduced tangs I've seen fail under Noss's 3-lb steel mallet were thinner tangs from other manufacturers. The Basic 9 tang remained straight under the weight-bearing "step" test and the flex test where he broke the tip, and when the B9 finally broke under heavy hammer blows to the handle, it was the blade that went--not the tang. So the significant weight savings in the reduced tangs on the Basics doesn't seem to result in a noticeable loss of strength, and actually, it's possible to go to a full .25" thick blade and still have a lighter knife with Resiprene, which actually makes for stronger prying. For example, the Basic 7 weighs about 12-12 1/2 oz with a 7" blade that's .25" thick, while an ASH1 LE weighs about 15 1/2 oz with a 6.5" blade that's .22" thick.
Plus, as Peter and LVC point out, the cushioning comfort of the Resiprene extends to vibration dampening and to insulation from extreme cold, also. Last weekend clearing trail, I went through a 5-inch diameter dried/seasoned juniper trunk (hard) with a Basic 11 that I would not ordinarily have attempted without gloves had I been using an FBM, because of vibration.