a knife is a knife...
I own Bussekin knives, but no Busse's yet.
I'll put it this way, if the world ended and I was the last person (or one of few) left alive, I would want a Busse on me, but it would not be my only knife I would want on me. The reason I say this is because warranty don't mean s**t if that is the situation, and from what I have seen their knives would stand the test of time, and be relatively easy to reshape/resharpen (could be wrong) if something were to happen to the edge.
It also depends what your going to be doing with it, if you are looking for a knife for bushcraft, or a hunting knife, or something to whittle sticks with, a Busse would not be MY first choice. I would go with a Nessmuck, Kephart, or mora type blade shape/grind type from a custom maker.
and good luck finding a model of Busse brand knife for a "reasonable" price on the secondary market. Getting one directly from the manufacturer I think their prices are just fine.
I personally like the style and look of Busse and Bussekin knifes, but they where not my first knife purchases, and like others have said, everyone is going to have a different type/style of knife that is their ultimate/ or appeals to that person.
If you are in love with their warranty, take a look at ESEE knives, they have the same warranty (if not a bit better, questionable, no reason to start an argument) and their prices and availability are amazing, for what you get; the down side is that these will rust if you do not keep them oiled, or are not using them, it will be surface rust, and no big deal, but that bothers some people.
All in all a custom is going to be just that, a custom or very limited number made, piece of work. A Busse/Bussekin, is what I would consider a semi-custom/semi-production, because of their availability and quality.
If I where you, I would do what I did, and buy multiple knives, and you will see that there is not really a "be all, end all" knife out there.
at least not that I have found one, and I don't own as many as some people that read/post on these forums, but I have a few.
Having said that, and being "into" knives, I like different things on different days. Heck, for what its worth, I used my Gerber (uh oh!) folding gator, all last year during hunting season, just because I hadn't used it in a long time, and it did just fine, could be a bit 'pointier' but like I said it got the job done.
sorry that got a little long, and it is just one persons opinion.