Resin bond stones don't like to be used dry, as they load up very quickly and glaze over. In fact, I find that any diamond stone cuts better and lasts longer with any liquid. Even just honing the edges of carbide inserts works better with a liquid than dry. Anyway, you will most likely need to dress the stone to get it back working as it should, but using it like it is won't hurt it until you do. Until you dress it, if it won't clean up with soapy water, try some alcohol, or Ajax, Comet, Barkeepers Friend, etc. The trick to using the Matrix stones is to use light pressure. Since I only use diamonds in them, they still cut with virtually no pressure. So, the less pressure used, the shallower the scratches, the keener the apex, the longer the stone will go between dressings, but the more strokes you will need.
As you said the Matrix 250 is a good one and done stone, especially if you finish with very light pressure and a light stropping to deburr.
As you said the Matrix 250 is a good one and done stone, especially if you finish with very light pressure and a light stropping to deburr.