I have large and small Grips and Delicas and Enduras. In both cases, I prefer the smaller knife for EDC (Delica & Mini Grip). I carried a Delica for over 10 years as my EDC, but pretty much never looked back after I got my first Mini Grip. Great ergos, blade/handle ratio, looks cool and the Axis lock is so quick and easy to use and put away that it has spoiled me for anything else.
From reading this, the ergos are a personal matter- as much as I like the thinness, lightness, slicing ability and extra length, I just can't love my flat ground Endura- the handle feels too thin for doing much real work with (hot spots!) and the balance doesn't feel right to me. I don't care much for the "clack" of the full-size Grip- but I put up with it for my matching numbered Ritters in M4. If you really need the full-size (and can afford it) I highly recommend the Gold Class Grip with CF handles (no clack) and M4 (yes, I know Spyderco does their M4 harder). It feels great in the hand. looks cool, and works really well.