I love me an Axis lock, but only own 1 of them. Go figure. I feel it's one of the best locks out there, as far as consistent lock-up, ease of use, and longevity.
Really, though, I prefer titanium frame locks, due to simplicity, and ease of use. As I'm right-handed, I have no issue with operation. It may actually be more of a material issue, as I can imagine loving a titanium-framed Axis lock, but haven't been able to find one I like, or can afford.
So, I guess I'd say my collection screams titanium frame lock, but my sub-conscious says Axis.
Most all other lock types are good, if done correctly, so I have no negative thoughts toward them. I even find that the twist-ring lock of Opinels are great!