So you buy exclusively CRK, Shiro, and Rockstead? I've either personally seen, or heard reports from reputable sources, of issues with brand new out of the box knives from pretty much any other brand I heard of.
I'm probably being overly snarky - apologies on that - but defects can happen from pretty much anyone - there's no such thing as 100% quality control. As others have stated, getting a brand new knife with a defect, and being expected to navigate the manufacturer's oft-serpentine warranty processes, is really too much to ask from almost anyone.
Also, my point on having a brick and mortar store around isn't so much about picking a defect-free copy of the knife as it is about trying the action and ergos in hand. A knife could be 100% defect free, look awesome in pictures, but you get it in hand and it's just not right for you - wrong shape, bad hotspots, etc. I know in that circumstance a lot of people would say "tough, you're stuck with it, sell in on the secondary", but I'll also disagree with that - if a store allows returns, you bought a knife in good faith but it just didn't work out, and it's unused and un-tampered with, by all means return it. Given that many manufacturers set MAP policies or other pricing restrictions, dealers are competing on other perks like customer service, including return policies. Returns are priced into their business model and expected - you're only hurting yourself if you choose not to use them.
As I mentioned in Sal's thread, I'd be much less likely to buy a knife that uses permanent Loctite or custom hardware - hell, I've passed on many interesting WE knives because of their star screws, and they even include the tool in the box. I would most likely outright reject any manufacturer that had a seal on the box itself, where breaking the seal prevents returns.