The 109 series was a very forward-thinking design, and the tactics they developed became the foundation of basically all modern Aerial combat. (high-speed, boom and zoom)
The Spitfire was one of the best of the "old" designs. (highly maneuverable, turn-type dogfighting.)
The Bf-109 could outrun almost any other plane of the period and had a very narrow rear profile. Also, it had a fuel injector, so the engines did not die if you dove too sharply, which was a problem for the British planes.
Basically, if you can trick a german pilot into a turning dogfight, you might win in a spitfire. If you don't see him coming and you don't have enough altitude, though, you are dead meat.
The BF-109s were harder to take off and land, which does take lives.
THe FW-190 was a kind of German version of the spitfire.
As to which one was most successful - The Israeli Air Force, when it was created in the late 40's, used the BF-109G or K, I think, which was one of the last models of that plane with a pressurized cabin for hi-altitude flight.