On the 110, the lock release is at the butt of the knife. On the Delica, the lock release is half way up the handle. That means that when you press it with your thumb, your hand is close enough to the blade to put your index finger in the Spydie hole and effect a safe and controlled closing of the blade to the one-third or half-way closed position. Then you must reposition your grip so that your other fingers are not in the blade path and complete the closing operation with your index finger on the blade spine.
This sounds more complicated than it is and can be done quite easily and quickly without moving the knife to your leg for something to press the blade spine against. I have always assumed that Spyderco favors the midway position for the lock release for this very reason (one-handed closing without using your leg). Note that with this method, the blade is never swinging freely toward your fingers. The video linked above shows this method once or maybe twice among countless other examples of the free-swinging blade method.
This mid-lock method is not quite as simple as closing an Axis which requires no change in grip. In fact, it is technically possible to do all of the following with an Axis and never change grip: open, make a light cut, and close. It is also possible to close an Axis without ever putting your fingers in the blade path, and that is almost impossible to do with a mid lock (for me at least). I'd give the edge to the Axis here, but the speed difference is not significant in actual use in my opinion (half second or so).