I think you probably have limited experience with knives in general if that is your view. Its not about having a full strength grip on a knife. Think about how little pressure it takes on a lockbar to prevent a detent from releasing a blade. Not much at all. And when I use my knives my grip is a full grip. the part of my hand right behind my index finger rests on the frame lock and it keeps the lock from disengaging. If you are opening mail maybe not. But any time I'm using my knife for a task that actually will benefit from having a lock in the first place you can bet your life I have a full grip and it does reinforce the lock. Most frame locks fail either due to slippage whether its from poor lock geometry or a slipper substance like oil getting on the lock face or a shock like dropping or smacking the spine of the knife. When you hold a knife with a frame lock gripping the handle you have constant pressure on the very end of the lockbar. How do you hold your knife? Like a tiny tea cup with your pinky extended? I know I don't. Remember the frame lock side is on your palm side. If you are a lefty using a right handed lock then I could see your fingers not doing that work.
Its pretty simple. If the lockbar cant move out of the way of the blade then the blade cant close. Is there a possibility that you could put so much force on the back side of the blade that its going to overcome your ability to hold the lockbar in place? Maybe. But I highly doubt it unless you just sit in your room replicating cold steel test videos. Also are you familiar with the rotoblock? It does exactly what your hand does when using a knife. It prevents the lockbar from moving out of the way of the blade. Anything that makes that fail, or if you grip cant prevent the lock from failing then you probably aren't doing something right. And just remember, you cant have two first of alls. You can have a first of all and a second of all, and maybe even your case a thirdly. But two first of alls? That is what I find more hard to believe.