Random Thought Thread

Jo the Machinist said:
Sadie still has bloody diarrhea. The vet said if there is a blockage it's moving through. There was a possible spot on the x-ray. He thinks most likely she ate something she shouldn't have. We got lots of medication. Jo needs your good vibes. In addition to Sadie now Abigail has the Rona. Jo's really tired.
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Wow. What a nightmare. Good vibes sent. Prayers sent, too.
 
bluemax_1 said:
Than explained by the number of cows PID'd with BSE, but service personnel stationed in the EU during the timeframe are barred from donating blood, due to the risk of possibly having consumed contaminated beef while stationed in the EU (and the fact that the prions/misfolded proteins, once consumed, remain in the body with the potential to cause Spongiform Encephalopathy many years or even decades later).

It's what worries me about CWD in cervids. It's caused by the same mechanism, i.e. prions/misfolded proteins.

BSE is now commonly accepted to have transferred from sheep with Scrapie (sheep form of SE), because UK farmers would feed sheep meat/bone meal to the cows as a cheap nutritional supplement.

Prions are scary, because they're just misfolded proteins. Because they aren't 'alive' they're extremely difficult to destroy.

To date, there isn't a confirmed case of vCJD attributed to CWD (that I'm aware of), but therein lies the problem; SE is caused by prions inducing/triggering a cascade of proteins misfolding in the host's body (and with BSE and vCJD, this can happen decades after consuming the affected beef products). Can we be sure that none of the vCJD cases in the US are related to CWD?

When BSE first popped up, we heard the same claims, "No evidence that consuming BSE beef has any proven ill effects in humans". Until vCJD.

What's even scarier is that we're now pretty sure that BSE was a species jump from sheep prions. Infected animals leave these prions in body fluids (saliva, blood, waste). The prions can endure in the environment for a long time and can be absorbed by the roots of plants, and be transported to the leaves/shoots. In the case of CWD, any cervid consuming these prion contaminated plants, can develop CWD.

They attempted to decontaminate a cervid farm in CO, going to the extent of removing the top soil, salting the whole area and covering it with new top soil, trucked in. Cervids reintroduced to the area quickly developed CWD.

If misfolded prions can cause SE in other species, and CWD infected cervids leave areas contaminated with prions, and other animals eat the plants, what are the possible ramifications? CWD infected deer wander and graze in areas that our cattle and sheep do.
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I literally could not understand any of that (except I think (?) that CO is Colorado), but none of it sounds any good.
 
bluemax_1 said:
Than explained by the number of cows PID'd with BSE, but service personnel stationed in the EU during the timeframe are barred from donating blood, due to the risk of possibly having consumed contaminated beef while stationed in the EU (and the fact that the prions/misfolded proteins, once consumed, remain in the body with the potential to cause Spongiform Encephalopathy many years or even decades later).

It's what worries me about CWD in cervids. It's caused by the same mechanism, i.e. prions/misfolded proteins.

BSE is now commonly accepted to have transferred from sheep with Scrapie (sheep form of SE), because UK farmers would feed sheep meat/bone meal to the cows as a cheap nutritional supplement.

Prions are scary, because they're just misfolded proteins. Because they aren't 'alive' they're extremely difficult to destroy.

To date, there isn't a confirmed case of vCJD attributed to CWD (that I'm aware of), but therein lies the problem; SE is caused by prions inducing/triggering a cascade of proteins misfolding in the host's body (and with BSE and vCJD, this can happen decades after consuming the affected beef products). Can we be sure that none of the vCJD cases in the US are related to CWD?

When BSE first popped up, we heard the same claims, "No evidence that consuming BSE beef has any proven ill effects in humans". Until vCJD.

What's even scarier is that we're now pretty sure that BSE was a species jump from sheep prions. Infected animals leave these prions in body fluids (saliva, blood, waste). The prions can endure in the environment for a long time and can be absorbed by the roots of plants, and be transported to the leaves/shoots. In the case of CWD, any cervid consuming these prion contaminated plants, can develop CWD.

They attempted to decontaminate a cervid farm in CO, going to the extent of removing the top soil, salting the whole area and covering it with new top soil, trucked in. Cervids reintroduced to the area quickly developed CWD.

If misfolded prions can cause SE in other species, and CWD infected cervids leave areas contaminated with prions, and other animals eat the plants, what are the possible ramifications? CWD infected deer wander and graze in areas that our cattle and sheep do.
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CWD - chronic wasting disease
 
bluemax_1 said:
Than explained by the number of cows PID'd with BSE, but service personnel stationed in the EU during the timeframe are barred from donating blood, due to the risk of possibly having consumed contaminated beef while stationed in the EU (and the fact that the prions/misfolded proteins, once consumed, remain in the body with the potential to cause Spongiform Encephalopathy many years or even decades later).

It's what worries me about CWD in cervids. It's caused by the same mechanism, i.e. prions/misfolded proteins.

BSE is now commonly accepted to have transferred from sheep with Scrapie (sheep form of SE), because UK farmers would feed sheep meat/bone meal to the cows as a cheap nutritional supplement.

Prions are scary, because they're just misfolded proteins. Because they aren't 'alive' they're extremely difficult to destroy.

To date, there isn't a confirmed case of vCJD attributed to CWD (that I'm aware of), but therein lies the problem; SE is caused by prions inducing/triggering a cascade of proteins misfolding in the host's body (and with BSE and vCJD, this can happen decades after consuming the affected beef products). Can we be sure that none of the vCJD cases in the US are related to CWD?

When BSE first popped up, we heard the same claims, "No evidence that consuming BSE beef has any proven ill effects in humans". Until vCJD.

What's even scarier is that we're now pretty sure that BSE was a species jump from sheep prions. Infected animals leave these prions in body fluids (saliva, blood, waste). The prions can endure in the environment for a long time and can be absorbed by the roots of plants, and be transported to the leaves/shoots. In the case of CWD, any cervid consuming these prion contaminated plants, can develop CWD.

They attempted to decontaminate a cervid farm in CO, going to the extent of removing the top soil, salting the whole area and covering it with new top soil, trucked in. Cervids reintroduced to the area quickly developed CWD.

If misfolded prions can cause SE in other species, and CWD infected cervids leave areas contaminated with prions, and other animals eat the plants, what are the possible ramifications? CWD infected deer wander and graze in areas that our cattle and sheep do.
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Prions, Dr. Gadusek, you may have come across him, one scary sick dude! Don't watch the Genius and the boys.

I was put off from ever seeing a doctor again.
 
Jo the Machinist said:
Sadie still has bloody diarrhea. The vet said if there is a blockage it's moving through. There was a possible spot on the x-ray. He thinks most likely she ate something she shouldn't have. We got lots of medication. Jo needs your good vibes. In addition to Sadie now Abigail has the Rona. Jo's really tired.
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Good vibes and prayers sent , God speed to both for feeling better soon and some rest for you
 
Cap’n Smudge said:
According to the Ohio department of natural resources (ODNR) the most common species of squirrel in Ohio is the flying squirrel. The other three species are red squirrel, fox squirrel and grey squirrel. I’ve personally seen these three species frequently. I’ve never seen a flying squirrel in Ohio in 40 or so years of living in Ohio. No shit - they must haul off the dead too because I have never even seen the remains of one. I have a few friends who are biologists and they assure me the flying squirrels are there but I don’t ever see them because they are nocturnal. I believe these people because they have no reason to lie to me about it and it is their field of study. But mostly I believe them because it puts “Sasquatch” back in the realm of possibility, and like Mulder, “I want to believe.”
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BTW, flying squirrels aren't just in OH.






It depends on what your neighbors are like.
 
Just "saved" about $1k for 2 knives that I wanted but missed out on here on the Exchange and on EB.

I seem to be "saving" more money than I'm spending on knives these days, which I guess is a "good thing" since I just spent $2k on new tires for the F250 and $1.4k for my share of a new fence for my house. So, it's not like I don't have other things that I need to spend money on.

Still have $300 in play for a knife that I want on EB to complete a vintage set. So, I still may get to spend some $ on knives yet.

LOL! ;)
 
Jo the Machinist said:
The area around us is well known for Bigfoot sightings. You need to come to the Gastonia area. You will see all the Bigfoot you ever wanted to.
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Unless your referring to Dan K I may have to pass on that one😂

I watched a squatch calling competition on YouTube once, it caused some pretty heavy second hand embarrassment 😳

And I hope Sadie pushes through, thoughts and prayers with you guys!
 
Jo the Machinist said:
The area around us is well known for Bigfoot sightings. You need to come to the Gastonia area. You will see all the Bigfoot you ever wanted to.
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I seen one
l7IB4kz.jpg
 
bluemax_1 said:
Than explained by the number of cows PID'd with BSE, but service personnel stationed in the EU during the timeframe are barred from donating blood, due to the risk of possibly having consumed contaminated beef while stationed in the EU (and the fact that the prions/misfolded proteins, once consumed, remain in the body with the potential to cause Spongiform Encephalopathy many years or even decades later).

It's what worries me about CWD in cervids. It's caused by the same mechanism, i.e. prions/misfolded proteins.

BSE is now commonly accepted to have transferred from sheep with Scrapie (sheep form of SE), because UK farmers would feed sheep meat/bone meal to the cows as a cheap nutritional supplement.

Prions are scary, because they're just misfolded proteins. Because they aren't 'alive' they're extremely difficult to destroy.

To date, there isn't a confirmed case of vCJD attributed to CWD (that I'm aware of), but therein lies the problem; SE is caused by prions inducing/triggering a cascade of proteins misfolding in the host's body (and with BSE and vCJD, this can happen decades after consuming the affected beef products). Can we be sure that none of the vCJD cases in the US are related to CWD?

When BSE first popped up, we heard the same claims, "No evidence that consuming BSE beef has any proven ill effects in humans". Until vCJD.

What's even scarier is that we're now pretty sure that BSE was a species jump from sheep prions. Infected animals leave these prions in body fluids (saliva, blood, waste). The prions can endure in the environment for a long time and can be absorbed by the roots of plants, and be transported to the leaves/shoots. In the case of CWD, any cervid consuming these prion contaminated plants, can develop CWD.

They attempted to decontaminate a cervid farm in CO, going to the extent of removing the top soil, salting the whole area and covering it with new top soil, trucked in. Cervids reintroduced to the area quickly developed CWD.

If misfolded prions can cause SE in other species, and CWD infected cervids leave areas contaminated with prions, and other animals eat the plants, what are the possible ramifications? CWD infected deer wander and graze in areas that our cattle and sheep do.
Click to expand...
Agreed. Prions for the most part have difficulty transmitting to a new species (e.g. BSE to humans) and while it was relatively quickly appreciated that BSE was amplified by feeding cattle back to cattle and once that practice was stopped the incidence of BSE, and subsequent exposure to humans, also went down. This same type of regulation was put into place and still exists in the US and, IMO, contributes to the few cases of BSE in the US (which are a sporadic form). CWD is a entirely different scenario where this is in wild cerivds, where it continues to expand its geographical range and incidence within endemic areas. What really bothers me about CWD is the continued widespread exposure of humans and other animals, some of which humans eat to CWD prions. Even if CWD has a really difficult time jumping to another species, if you give it enough opportunities that is not a good thing.
 
Jo the Machinist said:
Sadie still has bloody diarrhea. The vet said if there is a blockage it's moving through. There was a possible spot on the x-ray. He thinks most likely she ate something she shouldn't have. We got lots of medication. Jo needs your good vibes. In addition to Sadie now Abigail has the Rona. Jo's really tired.
Click to expand...
Hang in there Jo! I hope all are feeling better soon.
 
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