Yeah. The concerning bit is if the prion triggers the cascade in specific proteins in another species, it potentially results in easier subsequent in-species transmission.Agreed. Prions for the most part have difficulty transmitting to a new species (e.g. BSE to humans) and while it was relatively quickly appreciated that BSE was amplified by feeding cattle back to cattle and once that practice was stopped the incidence of BSE, and subsequent exposure to humans, also went down. This same type of regulation was put into place and still exists in the US and, IMO, contributes to the few cases of BSE in the US (which are a sporadic form). CWD is a entirely different scenario where this is in wild cerivds, where it continues to expand its geographical range and incidence within endemic areas. What really bothers me about CWD is the continued widespread exposure of humans and other animals, some of which humans eat to CWD prions. Even if CWD has a really difficult time jumping to another species, if you give it enough opportunities that is not a good thing.
Kind of a ticking timebomb, and we don't really know any effective ways to sterilize an area of contamination, ways to easily test to see who/what may have been exposed, any ways to eliminate prions once they're in the body, any way to inoculate a mammal against them, or how to stop the cascade or cure a victim.
