A lot's already been said, so I'll try not to reiterate or rehash anything too much.
I whole-heartedly agree that Spyderco's primary focus when it comes to pocket knife design tends to lean towards functionality in-hand. I work in a lumber yard and tend to carry larger folders (~4") for work use; because of my work attire (thicker and heavier work pants with lots of pockets), I don't mind the extra size and weight that Spyderco's tend to have on them in this environment (it often makes them feel better in my hand imho, ymmv). In fact, while I have several knives that I bring to work, including a BM 710, some of my favourites to bring and use are my Spyderco S110V Millie and my CPM154/S90V Manix because they are just such superb cutting tools and extremely comfortable for me to use!
However, while my work knives are pretty evenly split between, Benchmade, Zero Tolerance, and Spydercos, my outside of work EDCs are predominantly Benchmade's with only a single Spyderco, the lone one being a Para 3 that if I'm being honest with myself, doesn't see a whole lot of pocket time these days. While the Spydercos may (arguably) out-perform the Benchmades that I own in any cutting tasks I may come across due to thinner blade grinds, "better" steels (more wear resistance), etc.; the designs of Benchmade tend to best the Spydercos in pocket-ability while not giving up too much in the way of functionality/cutting ability (my personal opinion obviously, as well as a generalization; I realize Spyderco makes pocketable knives like the Delica and the Baby Jess Horn, but overall, I find their knives to be on the thicker and wider side of things - a sacrifice they have to make for their great ergonomics).
I can carry the same amount of blade in my 940 as my Manix, or the same amount of blade in my Para 3 in my 707 or 485, but in a more size-efficient package which makes it much easier for me to carry in the clothes I wear on my own time (lighter, fewer pockets, less heavy-duty fabric/construction). And for my EDC cutting tasks, any difference in performance is outweighed by the weight and size savings, as well as the fact that I'm unlikely to be doing any extended cutting with my EDC.
TL;DR To summarize and draw some personal conclusions:
1) Generally speaking, I find Spydercos edge out my Benchmades in the cutting department - they are great cutting tools, but often are pocket hogs when compared with their same-size counterparts from other makers; ymmv.
2) I find that Benchmade tends to strike a better all-around balance between cutting ability and being pocketable with a deference to the later if anything - which sometimes costs them in the cutting/slicing department due to limitations of a given knife's design