The spydie hole is the most positive one handed opening method of any folding knife. It works by feel - in the dark, in the water or wherever. In its early days it was embraced by the climbing fraternity for that very reason.
I own flippers and stud openers and most other variations and while they are interesting and fun they all require deliberate positioning of the grip and careful manipulation.
The spydie just works, under all sorts of conditions. The ability to flick it open is more a function of the locking mechanism than the spydie hole.
I agree. I've been through a lot of knives and I find the spyderhole to be the easiest and most positive way to open a knife, usually the fastest too. From the first time I saw a thumbstud I have liked them and used them. I find that with various knives the thumb studs are hard to get your thumb on because the handle is in the way, the thumb studs are such that they don't give good traction for your thumb and your thumb can and will slip off. I have to carefully position my thumb on the thumb stud and concentrate on opening the blade, and sometimes the thumb still slips off. This all takes time and takes your focus off of the job at hand. Even an assisted knife with thumb studs can be slow to open for this reason. I find a similar problem with my ZT knife with flipper. I have to carefully position my finger in order to open the knife. My one exception was my Kershaw Blur- the thumb stud on that one was big and had sharp edges so it was easy to get the needed traction to open it. The thumb hole is easy to hit with my thumb and provides good traction so it is easy and quick to open a blade like this. But all thumb holes are not created equally, some Spyderco holes are larger and those are easier for me to use. I have some old Benchmades with holes but those knives have chamfers at the hole edges which affects traction and sometimes my thumb can slip out of the thumb hole.