I think this focus on opening speed is misguided. I've practiced both tip-up and tip-down, they're roughly the same speed. I think if anyone is seeing any differences in opening speed worth mentioning, they probably haven't practiced enough yet with the slower-type opening. I do feel one is a hair faster than the other, but so what? That 1/100th of a second probably doesn't matter either way.
Two things that *do* matter to me are 1) security in the pocket, and 2) security while opening. Tip-down has the nod for security in the pocket -- for tip-up, you really do want some good spring pressure to make sure the blade stays closed. For security while opening, tip-up has the nod -- you do not need to pinch-grip for a fast tip-up opening, something you'll always end up doing at some point or other for fast tip-down opening. The get the same security with tip-down opening, you have to slow down a bit.
So with any knife that holds the blade in the handle firmly, tip-up is a pretty clear winner, in my opinion.
On the other hand, I'll say again this issue for me is secondary to the other clip issues. The clip has to be mounted high, and it should not interfere with the ergonomics. Many companies and makers break one or the other of these two most important rules, in a misguided attempt to ensure tip-up or tip-down.
For an example of proper clip positioning, check out Darrel Ralph's Krait. There's no way he could have done a high-mounted tip-up clip, so he made it a high-mounted tip-down clip. The clip is shaped well and angled in such a way that it doesn't interfere with the ergonomics at all. Most important thing to watch out for with tip-down clips is making sure the clip doesn't get in the way of the thumb stud/hole/disk or lock area. I'm a tip-up fan, but tip-down was the right choice for the Krait.
Joe
jat@cup.hp.com