Man eating carnivors are certainly a concern/problem, but what about mice? Mice can move in and do alot of damage in short order. They move in take over and do allot of damage, stink up the place and chew everything to bits and spread disease. Every summer and fall they come crawling and chewing through the walls and one has to keep up steady baiting and replacing traps. Having served on our vollunteer fire department we have gone to several fires that were started by mice chewing through wiring.
Please read thi s all the way through, as I do not think of myself as bullet proof to the stress large predators can bring on a human.
I'm a young guy. My wilderness experiences are nothing compared to many on this forum, but for me, I have at least chewed some of the same dirt as some well respected outdoorsmen. Recently Living up in the Appalachians, I consider bears a slight nuisance. I've encountered about 5 or 6 in the wild, all going the other direction once I professed hostility, or made my presence known. After purchasing a light weight 357 mag., I feel a little better even after that. Please keep in mind I don’t sleep in grizzly country, but Black Bears do not keep me up at night.
As far as mountain lions. I spent my adolescent life 1 mile from Mt. Diablo in California. Every weekend just about, I would mtn bike and camp up there alone. Never a problem. Sure the littlest rustle from whatever it was outside my tarp woke me up, but I never was really apprehensive just cause of a mtn lion threat. (didn't have a .357 then though

). I never saw a Mtn Lion while I was there. I promised I wouldn’t become a statistic and slept close to a few knives I know I could grab when it hit the fan, critter wise. There, I was never kept up at night.
Coyotes? I now type on a dock, in the middle of no-where, South Carolina. I have internet connection (3g), but I can’t call my wife on the phone. Don't ask me how that works….Parallel from me, about 200 yards, is a camp site I like to stay at, where I was surrounded in a hammock (human burrito) by a pack of coyotes howling and carrying on. As soon as I moved, it was like walking in on a teenager that snuck their boyfriend into the room and didn't expect to get caught. They were dumbstruck, and then they panicked and scattered. Also happens every time I make my presence known when I'm in a stand. I type this and hear them howling. I’m not worried about coyotes unless my dog is missing. I’ve had a pack in my campsite, but once again, not enough to keep me up at night.
Everglades cured me of any python worries after catching a couple dozen. The Copperhead bite I've had, plus my love/ obsession for snakes and figuring out the biology behind them, writes me off for that. It isn’t fair to say I’m not afraid of snakes as I love and go looking for them. I just respect them.
Bugs....well, I wouldn't go stick my hand in a fire ant mound. or go to a place fervent with ticks that are known to carry Ehrlichiosis, Lyme, and Rickettsia thought I've done both on accident, and used knowledge (remove ticks within 24 hours) to help treat my stupidity at the time. I have a Minor in Entomology, so when an insect is vexing me I am morbidly fascinated. Not so popular with my friends.
Ok. I admit to having a few second thoughts in Mtn. Lion country, and even in places where bear problems have been, but what I am trying to profess is that none of these have kept me up at night…
But what has?
The biggest psychological onslaught, and the nights of torment that made me nervous, sleepless, restless, and awoken with my anger batter on full charge, were due to mice.
I'm a backpacker and an avid camper. In these situations, I've found myself in shelter after Shelter on the Appalachian trail, sea to mountains trail, and a host of other backwoods campsites. The problem with these is that the mice there have grown...well smart. Smarter than me ; to tell you the truth. Despite my love for animals and my degree in Zoology, Mice have robbed me more hours of sleep than I should like to admit. I remember one night, near Mt. Leconte off the AT, where it was my own vendetta, to stomp, smother, baton, and molest every mouse that was in the shelter. It all started with the previous night. I had mice skitter over my sleeping bag, and even across my face. I KNEW I had heard one chomping on my down bag even in 10 degree weather. Shouldn't that little twirp have been sleeping or hibernating? Hell no, these were human tolerant mutant x-gene mice that could work a residential redneck to lose their wits. They messed with me mentally until you could visibly see the brown puddles under my eyes spread.
The next morning, despite all the normal precautions and food cooking, I found 3 holes chewed in my $200 backpack. On my nice sleeping bag, there was a hole on the side, at the bottom, where some female vermin decided to extract my thermo-regulating fibers of my hollowfil bag to help insulate her progeny. Meanwhile, the bear bag outside, despite all my carefulness, had looked like it was set upon by surgical smurfs with chainsaws.
The next AT shelter had the same result. I was repeatedly awoken by these brave mice scurrying over my bag, not caring. Never before in my life had I ever had to combat such an enemy. My cabin mates dealt with it, in a symphony of uncomfortable sighs, mumbling, and shuffling.
I set up traps, threw rocks, and succeeded in killing 4 mice that night, in this shelter, in a combination of pan traps, violence, and patience. The sad part was we met a camper in a different shelter the next day, that had the same experience, despite my pest control attempt.
So, in my years of camping experience, in jungles, everglades, mtn. lion hunting grounds, mosquito infested, venomous snake saturated, bear habitat and even rednecks, nothing has robbed me of sleep, and made me paranoid, like the normal determined field mouse. I've found this experience on multiple occasions now, and if I am sleeping in an AT shelter, I now pack traps.
Those mice work people like a seasoned card manipulator in a Las Vegas Blackjack competition.